An assessment of InP/ZnS as potential anti‐cancer therapy: Quantum dot treatment induces stress on HeLa cells
نویسندگان
چکیده
InP/ZnS quantum dots (QDs) are an emerging option in QD technologies for uses of fluorescent imaging as well targeted drug and anticancer therapies based on their customizable properties. In this study we explored effects when treated with HeLa cervical cancer cells. We employed XTT viability assays, reactive oxygen species (ROS) analysis, apoptosis analysis to better understand cytotoxicity extents at different concentrations InP/ZnS. addition, compared the transcriptome profile from QD-treated cells that untreated identify changes response QD. Resulting RNAseq data illustrated mode action within cell. Our determined both IC50 concentration 69 µg/mL MIC 167 It was observed via assay cell decreased significantly MIC. Production superoxide, measured by ROS flow cytometry, decreased, whereas levels peroxynitrite increased. Using apoptosis, found induced death samples shown be increased conclude decrease inducing stress levels, induction, alteration transcriptome.
منابع مشابه
SILAR Sensitization as an Effective Method for Making Efficient Quantum Dot Sensitized Solar Cells
CdSe quantum dots were in situ deposited on various structures of TiO2 photoanode by successive ionic layer adsorption and reaction (SILAR). Various sensitized TiO2 structures were integrated as a photoanode in order to make quantum dot sensitized solar cells. High power conversion efficiency was obtained; 2.89 % (Voc=524 mV, Jsc=9.78 mA/cm2, FF=0.56) for the cells that sensitized by SILAR meth...
متن کاملassessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
چکیده ندارد.
15 صفحه اولEffect of PbS Film Thickness on the Performance of Colloidal Quantum Dot Solar Cells
Colloidal quantum dots offer broad tuning of semiconductor band structure via the quantum size effect. In this paper, we present a detailed investigation on the influence of the thickness of colloidal lead sulfide (PbS) nanocrystals (active layer) to the photovoltaic performance of colloidal quantum dot solar cells. The PbS nanocrystals (QDs) were synthesized in a non-coordinating solvent, 1-oc...
متن کاملThimerosal induces oxidative stress in HeLa S epithelial cells.
Thimerosal is one of the most widely used preservatives and is found in a variety of biological products, including vaccines, contact lens cleaning solutions, and cosmetics. It has been reported to have harmful effects on epithelial tissues, such as causing conjunctivitis or contact dermatitis. However, the molecular mechanism of its toxicity has not been characterized using epithelial tissues....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: ['0892-6638', '1530-6860']
DOI: https://doi.org/10.1096/fasebj.2021.35.s1.02764